Clomid (Clomiphene Citrate): Pharmacology and Effectiveness

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Clomid as a Strong Hormonal AgentClomid (clomiphene citrate) is a highly effective medicine affecting the hormone balance of a female body, as well as the functioning of the reproductive system. The strong-acting nature of this medication is the reason why patients should study the instructions attentively and carry out all the recommendations specified.

Instructions for Use of Clomiphene Citrate

Clomid tablets should be taken orally with a glass of water. Administration of the medicine does not depend on your eating regimen.

The first necessary step before beginning the therapy with clomiphene citrate is determination of the hormone levels. Your doctor will establish the initial dosage based on your hormone test results.

The treatment course for anovulation with clomiphene citrate starts from the fifth day of your menstrual cycle. Female patients who do not show significant divergences in a hormonal background should take 1 tablet in the evening or before sleep. The treatment duration is 5 days.

If not successful at getting pregnant at the first therapeutic attempt, the patient should renew the administration of Clomid during her next menstrual cycle, with the dosage increased. During her second attempt, the patient should take 100 mg of the drug (2 tablets) per day for six days. In absence of the desired result, one last third attempt is allowed.

In cases where the therapy has proved unsuccessful all the three times, it is necessary to take a small break for 2-3 months and stop taking the medicine to induce ovulation. After these 2-3 months, the patients may go through three more attempts. If no effect has been reached, the further administration of clomiphene citrate is not advised. However, hopeless cases with this drug are extremely rare.

During treatment, the woman should be regularly observed by her attending gynecologist. Your healthcare expert will regularly check the ovary function, survey your vagina, and estimate the reaction of your organism to Clomid. Depending on the results, the doctor may adjust the dosage to increase the therapeutic effectiveness.

Warnings Related to the Use of Clomid

A study back in the mid-1990s suggested that, after more than six treatment cycles with Clomid, the risk of ovarian cancer may increase in later years. Further studies could not find a strong link between fertility drugs and ovarian cancer. The research data indicate that it is more probable for the infertility issue to increase the risk of cancer and not the fertility drug with which it is treated.

Women who take clomiphene citrate along other fertility drugs, such as human menopausal gonadotropin (hMG, also referred to as menotropin), have a potential to develop ovarian hyperstimulation syndrome (OHSS) — although this rarely happens with Clomid alone. OHSS may grow into a serious condition, which is also indicated by weight gain and a feeling of fullness caused by the accumulation of water in the abdominal cavity and ovaries. OHSS occurs when a patient reacts too well to the drug and produces too many eggs. Usually, this issue subsides as you abandon the therapy. However, experts advise close supervision by the doctor because, in very rare cases, OHSS can also be life-threatening.

Chances of success with Clomid

The success statistics with Clomid split into two factors: the rate of ovulation and a chance of pregnancy. Fertility drugs are quite successful at stimulating the ovulation: over 70 percent of female patient ovulate, most of them within the first three months of treatment. And from these women, 15 to 50 percent get pregnant.

This wide range of success rates is explained by all the other factors that influence your pregnancy, namely the timing of your sexual intercourse cycle, your age and weight, as well as your partner’s sperm count and motility.

Another aspect of ovulation-stimulating medications is that they can cause a release of more than one egg, thus increasing the chance of multiple pregnancy. Women who take Clomid have been shown to have about a 7 percent chance of giving birth to twins and a 0.5 percent of triplets.